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Updated: Jun 12, 2026
04:48
Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography
Published on: November 30, 2022
Orbital involvement in Bing-Neel syndrome
Rebecca C Stacy1, Frederick A Jakobiec, Fred H Hochberg
1Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
Summary
Bing-Neel syndrome (BNS), a rare intracranial manifestation of Waldenström macroglobulinemia (WM), can involve the orbit and optic nerves. Prompt diagnosis and a comprehensive treatment strategy, including chemotherapy and stem cell transplant, led to resolution of neuro-ophthalmic symptoms.
Area of Science:
- Neurology
- Ophthalmology
- Hematology
Background:
- Bing-Neel syndrome (BNS) is characterized by the central nervous system involvement of Waldenström macroglobulinemia (WM).
- Orbital and optic nerve involvement in BNS is exceptionally rare, with limited documented cases.
Observation:
- A 51-year-old male patient with a history of WM presented with bilateral orbitopathy and optic neuropathy.
- Clinical presentation included symptoms affecting the eyes and vision, prompting further investigation.
Findings:
- Diagnosis was confirmed through orbital biopsy, cerebrospinal fluid analysis, and neuroimaging.
- BNS involvement extended to orbital soft tissues, optic nerves, meninges, and the cauda equina.
Implications:
- The case highlights the potential for BNS to manifest with rare neuro-ophthalmic symptoms.
- Successful treatment involved a multimodal approach including parenteral and intrathecal chemotherapy, and autologous stem cell transplantation.
- This suggests that a comprehensive therapeutic strategy is crucial for managing rare BNS presentations.
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