Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The dual targeting effects of KD025 on casein kinase 2 and ROCK2 in a mouse model of diet-induced obesity.

Biochemical pharmacology·2025
Same author

Lysophosphatidic Acid Induces Podocyte Pyroptosis in Diabetic Nephropathy by an Increase of Egr1 Expression via Downregulation of EzH2.

International journal of molecular sciences·2023
Same author

Bavachin alleviates diabetic nephropathy in db/db mice by inhibition of oxidative stress and improvement of mitochondria function.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2023
Same author

The Inhibition of Autophagy and Pyroptosis by an Ethanol Extract of <i>Nelumbo nucifera</i> Leaf Contributes to the Amelioration of Dexamethasone-Induced Muscle Atrophy.

Nutrients·2023
Same author

Bavachin and Corylifol A Improve Muscle Atrophy by Enhancing Mitochondria Quality Control in Type 2 Diabetic Mice.

Antioxidants (Basel, Switzerland)·2023
Same author

LPA/LPAR1 signaling induces PGAM1 expression via AKT/mTOR/HIF-1α pathway and increases aerobic glycolysis, contributing to keratinocyte proliferation.

Life sciences·2022

Related Experiment Video

Updated: Jun 12, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

Cell replacement and regeneration therapy for diabetes.

Hee-Sook Jun1

  • 1Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon, Korea.

Korean Diabetes Journal
|June 16, 2010
PubMed
Summary

Restoring beta cell function is key for diabetes treatment. Regenerative approaches using stem cells offer potential, but ensuring fully functional and safe cells is crucial for clinical success.

Keywords:
Beta cellDiabetes mellitusDifferentiationIslets of LangerhansRegenerationStem cells

More Related Videos

In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas
09:31

In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas

Published on: June 10, 2016

Related Experiment Videos

Last Updated: Jun 12, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas
09:31

In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas

Published on: June 10, 2016

Area of Science:

  • Endocrinology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Type 1 and type 2 diabetes are characterized by reduced beta cell function and mass.
  • Restoring beta cell function represents a potential therapeutic strategy for diabetes.
  • Islet transplantation offers benefits like reduced hypoglycemia and insulin independence but faces donor scarcity.

Purpose of the Study:

  • To explore regenerative approaches for beta cell/islet therapy.
  • To identify potential cell sources for beta cell regeneration.
  • To highlight critical factors for clinical application of regenerated beta cells.

Main Methods:

  • Investigating in vitro differentiation of various cell types into insulin-producing cells.
  • Exploring in vivo regeneration of pancreatic beta cells.
  • Reviewing the potential of embryonic and adult stem cells, pancreatic ductal progenitor cells, acinar cells, and other endocrine cells.

Main Results:

  • Multiple cell types, including stem cells and progenitor cells, can differentiate into pancreatic beta cells.
  • Both in vitro and in vivo strategies are being pursued for beta cell regeneration.
  • The study identifies key challenges in achieving functional and safe beta cell regeneration.

Conclusions:

  • Beta cell regeneration holds promise for diabetes treatment by addressing functional deficits.
  • Successful clinical application hinges on generating fully functional and safe insulin-producing cells.
  • Further research is needed to overcome challenges in beta cell regenerative therapy.