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[Idiopathic thrombocytopenic purpura in children treated with replenishing qi and tonifying kidney and the changes in
Insights
This study found that replenishing Qi and tonifying Kidney therapies are effective for treating childhood idiopathic thrombocytopenic purpura (ITP), with a high recovery rate and sustained remission.
Area of Science:
- Integrative Medicine
- Pediatric Hematology
- Traditional Chinese Medicine (TCM)
Context:
- Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder affecting children.
- TCM categorizes ITP into patterns like blood-heat and Qi/Kidney deficiencies.
- This study investigated TCM treatment for pediatric ITP.
Purpose:
- To evaluate the efficacy of TCM-based treatment for childhood ITP.
- To assess treatment outcomes and recurrence rates.
- To analyze the effect on platelet aggregation function.
Summary:
- Forty-one children with ITP were treated using TCM principles, with 24 classified as blood-heat and 17 as Qi/Kidney deficiencies.
- The treatment involved specific herbal prescriptions over an average of 5.02 months.
- A total effective rate of 97.6% was achieved, with 22 patients showing no recurrence during follow-up.
Impact:
- TCM treatment demonstrated significant effectiveness in curing or improving pediatric ITP.
- The therapy normalized platelet aggregation function, suggesting a mechanism of action.
- Replenishing Qi and tonifying Kidney approaches show promise for long-term management of pediatric ITP.
Unlabelled:
Forty-one children with idiopathic thrombocytopenic purpura (ITP) were reported in this paper. Of all, 36 with petechia and ecchymosis, 28 with nasal hemorrhage, 5 with hematochezia and 1 with subcutaneous hematoma. According to the TCM differentiation, 24 and 17 of all belonged to the type of impairment of Yin due to blood-heat and both deficiencies of Qi and tonifying Kidney and its basic prescriptions were: dried Radix Rehmanniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Radix Rubiae, Fructus Psoraleae, stir-frying Radix Astragali, Semen Cuscutae, Caulis Spatholob; Chinese Jujubae, Radix et Rhizoma Rhei. The average treating duration was 5.02 months.
Results:
24 cases cured, 6 recovered, 10 improved, 1 failed, with a total effective rate of 97.6%. 22 of the cured were followed-up without recurrence in average 10.4 months after withdrawal. In 32 cases, the thrombocyte aggregative function was tested with ADP induction, meanwhile in 20 of 32 cases aggregation with adrenaline induction was tested. The results before and after treatment showed an evident difference, with low function before treatment and normal after treatment. It is concluded that the replenishing Qi and tonifying Kidney may have a better effect on both acute and chronic children ITP without recurrence after withdrawal.
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