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Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
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Published on: June 22, 2012

A Hydroxyurea-induced Leg Ulcer.

Seon-Wook Hwang1, Soon-Kwon Hong, Sang-Hyun Kim

  • 1Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.

Annals of Dermatology
|June 16, 2010
PubMed
Summary
This summary is machine-generated.

Hydroxyurea, a treatment for myeloproliferative diseases, can cause rare leg ulcers. Discontinuing hydroxyurea led to the healing of leg ulcers in a Korean patient, suggesting a causal link.

Keywords:
Cutaneous side effectsHydroxyureaLeg ulcer

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Area of Science:

  • Dermatology
  • Hematology
  • Pharmacology

Background:

  • Hydroxyurea is a standard treatment for myeloproliferative neoplasms.
  • Cutaneous side effects of hydroxyurea are common, including xerosis and hyperpigmentation.
  • Leg ulcers are a rare but serious adverse effect of hydroxyurea therapy.

Observation:

  • A 75-year-old woman with essential thrombocytosis presented with refractory leg ulcers, nail discoloration, and xerosis.
  • The patient had been on oral hydroxyurea since 2002.
  • Conventional treatments for the leg ulcers were ineffective.

Findings:

  • Hydroxyurea-induced leg ulcers were suspected due to the patient's history and refractory symptoms.
  • Discontinuation of hydroxyurea treatment resulted in the gradual healing of the leg ulcers.
  • This case highlights a rare adverse reaction to hydroxyurea in a Korean patient.

Implications:

  • Hydroxyurea treatment requires careful monitoring for potential cutaneous side effects, including leg ulcers.
  • Early recognition and discontinuation of hydroxyurea may be crucial for managing these ulcers.
  • This case contributes to the understanding of hydroxyurea's dermatological toxicity in diverse populations.