Related Experiment Video
Updated: Jun 12, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
A case of hydroxychloroquine induced acute generalized exanthematous pustulosis confirmed by accidental oral
Jae-Jeong Park1, Sook Jung Yun, Jee-Bum Lee
1Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
Abstract:
Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and this is characterized by acute, nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ) has been widely used to treat rheumatic and dermatologic diseases and HCQ has been reported to be an uncommon cause of AGEP. A 38-year-old woman with a 1-year history of dermatomyositis and polyarthralgia was treated with HCQ due to a lack of response to a previous medication. Three weeks after starting HCQ therapy, the pustular skin lesion developed and then this resolved after the HCQ was withdrawn and steroid treatment was started. A similar pustular eruption developed after HCQ was accidentally readministered.
Related Concept Videos
Drug Toxicity: Allergic Reactions
Hypersensitivity Reactions: Immune-Complex Reactions
Chickenpox
Smallpox
Hypersensitivity Reactions: Cytolytic Reactions
Herpes
