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Related Experiment Video

Updated: Jun 12, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Chemical Leukoderma Improved by Low-dose Steroid Pulse Therapy.

Jae Yoon Jung¹, Kkot Bora Yeom, Hee Chul Eun

¹Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Annals of Dermatology

|June 16, 2010

Summary

Chemical leukoderma, caused by chemical exposure, presents challenges in diagnosis and treatment. Systemic steroid pulse therapy shows promise for treating this condition, offering a potential new treatment option.

Keywords:

Chemical leukoderma Systemic steroid Vitiligo

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Last Updated: Jun 12, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Dermatology
Toxicology
Pathology

Background:

Chemical leukoderma results from toxic chemical exposure, affecting melanocytes.
Distinguishing chemical leukoderma from vitiligo clinicohistopathologically is challenging.
Diagnosis relies on a history of exposure to depigmenting agents.

Observation:

A case report of a 51-year-old man with hypopigmented lesions after occupational chemical exposure.
Lesions were unresponsive to topical corticosteroids.
Significant improvement was observed after systemic steroid pulse therapy.

Findings:

Systemic steroid pulse therapy demonstrated efficacy in treating chemical leukoderma.
The patient experienced marked improvement in depigmented macules and patches.
This suggests a potential treatment avenue for recalcitrant cases.

Implications:

Systemic steroid pulse therapy may be a viable treatment option for chemical leukoderma.
Further research is warranted to establish treatment guidelines.
Understanding the mechanism of melanocyte damage is crucial for developing targeted therapies.