Related Experiment Video
Updated: Jun 12, 2026

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
Published on: March 28, 2025
Huge hydrocephalus: definition, management, and complications
Morteza Faghih Jouibari1, Nazanin Baradaran, Rouzbeh Shams Amiri
1Department of Neurosurgery, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran.
Insights
Management of huge hydrocephalus (HH) in infants requires careful consideration due to high complication rates. Programmable shunts are recommended to control drainage and mitigate risks like infection and developmental delays.
Area of Science:
- Pediatric Neurosurgery
- Neurology
- Medical Management
Background:
- Huge hydrocephalus (HH) presents unique challenges compared to common hydrocephalus.
- Parental socioeconomic factors and lack of knowledge can lead to delayed treatment, resulting in progressive HH and macrocephaly.
- Effective management strategies are crucial for improving outcomes in infants with HH.
Purpose of the Study:
- To present the clinical experience in managing infants with huge hydrocephalus (HH).
- To analyze the causes, treatment outcomes, and complications associated with HH management.
- To highlight the importance of appropriate shunt technology in HH patients.
Main Methods:
- Definition of HH: head circumference greater than infant's height.
- Surgical intervention involved shunting in nine infants diagnosed with HH.
- Follow-up duration ranged from 0.5 to 7 years post-shunting.
Main Results:
- Aqueductal stenosis was the most frequent cause of HH.
- The average age at shunting was 3 months, with head circumferences averaging 67 cm (range 56-94 cm).
- Five patients had age-appropriate cognitive status, but only one showed normal motor development. Complications included subdural effusion (6), shunt infection (4), and mortality (3) due to infection/sepsis.
Conclusions:
- Patients with HH face significant risks of complications post-shunt surgery, including subdural effusion, ventricular collapse, and shunt infection.
- Mental and motor disabilities are prevalent in infants with HH.
- Programmable shunts are advised to control overdrainage, a potential cause of complications.
Objective:
Lack of comprehensive knowledge and numerous socioeconomic problems may make the parents leave hydrocephalic children untreated, leading to progressive hydrocephalus and eventual unordinary big head. Management of huge hydrocephalus (HH) differs from common hydrocephalus. We present our experience in the management of these children.
Methods:
HH is defined as head circumference larger than the height of the infant. Nine infants with HH have been shunted in Children's Hospital Medical Center and followed up for 0.5 to 7 years.
Results:
The most common cause of hydrocephalus was aqueductal stenosis. The mean age of patients during shunting was 3 months. The head circumference ranged from 56 to 94 cm with the average of 67 cm. Cognitive statuses were appropriate based on their age in five patients. Motor development was normal only in one patient. Complications were found in most cases which included subdural effusion (six patients), shunt infection (four patients), skin injury (three patients), proximal catheter coming out of ventricle to the subdural space (two patients), and shunt exposure (one patient). Three patients died due to shunt infection and sepsis.
Conclusion:
Numerous complications may occur in patients with HH after shunt operation such as subdural effusion, ventricular collapse, electrolyte disturbance, skull deformity, scalp injury, and shunt infection. Mental and motor disabilities are very common in patients with HH. Many of these complications can be related to overdrainage; therefore, drainage control using programmable shunts is advisable.
Related Concept Videos
Increased Intracranial Pressure l: Introduction
Cerebral Edema l: Introduction
Cerebral Edema ll: Pathophysiology
Increased Intracranial Pressure ll: Pathophysiology
Brain Abscess l: Introduction
Cytotoxic Edema: Pathophysiology
