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Published on: January 17, 2018
Apoplexy in pituitary microadenomas
Benjamin R Randall1, William T Couldwell
1Department of Neurosurgery, University of Utah, Salt Lake City, 84132, USA.
Abstract:
Pituitary apoplexy is a clinical syndrome of hemorrhage or infarction of a pituitary adenoma. It has classically been associated with pituitary macroadenomas. The authors report three cases of pituitary apoplexy that occurred in patients with pituitary microadenomas. The presentation, endocrine results, and radiological and clinical outcome of each patient are described. In each of these cases of pituitary apoplexy due to microadenoma, the presenting headache was mistakenly attributed to a different diagnosis. The authors propose that pituitary apoplexy associated with a microadenoma may be much more common than appreciated and could be misdiagnosed as headache of alternative cause. Clinicians and radiologists should be aware of this clinical presentation.
Insights
Pituitary apoplexy, a rare complication of pituitary adenomas, can occur with smaller pituitary microadenomas. This condition may be frequently misdiagnosed as a common headache.
Area of Science:
- Endocrinology
- Neurology
- Radiology
Background:
- Pituitary apoplexy is a rare clinical syndrome typically linked to pituitary macroadenomas.
- It involves hemorrhage or infarction within a pituitary adenoma.
Observation:
- This study presents three cases of pituitary apoplexy occurring in patients with pituitary microadenomas.
- The clinical presentation, endocrine status, and outcomes were documented for each patient.
Findings:
- Headaches in these microadenoma cases were initially misdiagnosed as unrelated conditions.
- Pituitary apoplexy associated with microadenomas may be underdiagnosed.
Implications:
- Increased awareness among clinicians and radiologists is crucial for accurate diagnosis.
- Recognizing pituitary apoplexy in microadenoma patients can prevent delayed treatment.
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