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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Jun 12, 2026

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
07:59

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

Clinical developments in nanotechnology for cancer therapy.

Jeremy D Heidel1, Mark E Davis

  • 1Calando Pharmaceuticals, Pasadena, California, USA.

Pharmaceutical Research
|June 16, 2010
PubMed
Summary

Nanoparticle drug delivery systems offer improved cancer treatment by targeting cancer cells more precisely, reducing side effects. This review covers clinical technologies, therapeutic molecules, and targeting strategies for nanomedicines.

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Area of Science:

  • Oncology
  • Nanomedicine
  • Pharmacology

Background:

  • Nanoparticle-based drug delivery systems are emerging as a promising strategy in cancer therapy.
  • These systems aim to enhance therapeutic efficacy and reduce systemic toxicity by selectively targeting cancer cells.

Purpose of the Study:

  • To review current nanoparticle drug delivery technologies investigated in clinical settings for cancer treatment.
  • To discuss the incorporation of various therapeutic molecules into nanostructured entities.
  • To explore the impact of nanotherapeutics on efficacy, safety, pharmacokinetics, and biodistribution.

Main Methods:

  • Focus on clinically investigated nanoparticle technologies.
  • Analysis of therapeutic molecules encapsulated within nanoparticles.
  • Review of studies examining the effects of nanotherapeutics on efficacy and safety parameters.
  • Discussion of advances in ligand-based nanoparticle targeting.

Main Results:

  • Nanoparticle drug delivery can significantly improve patient care by reducing off-target toxicities.
  • Selective targeting of cancer cells enhances drug molecule delivery to intracellular sites.
  • Pharmacokinetics and biodistribution are key parameters influenced by nanostructured therapeutics.
  • Recent advances have improved the understanding of ligand-receptor interactions in nanoparticle targeting.

Conclusions:

  • Nanoparticle drug delivery holds significant potential for revolutionizing cancer treatment.
  • Further research into nanomedicine targeting strategies can optimize therapeutic outcomes.
  • Clinical translation of nanotherapeutics promises improved safety and efficacy in oncology.