Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions.

Science (New York, N.Y.)·2026
Same author

Monocyte Chemokines Enhance Atherosclerotic Plaque Necrosis After Bacterial Kidney Infection.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Predicting Macrophage Spatial Localization from Single-Cell Transcriptomes to Uncover Disease Mechanisms.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Sodium glucose transporter 2 inhibition maintains kidney antibacterial response by decreasing complement C1q.

Kidney international·2026
Same author

Subcellular glycan-mannose receptor binding kinetics correlate with myeloid cell function.

Nature communications·2025
Same author

High-salt diet induces immune-independent re-differentiation, metabolic shut down and cell cycle arrest of melanoma.

Cell death & disease·2025

Related Experiment Video

Updated: Jun 12, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Dendritic cells erase bad memory.

Christian Kurts1

  • 1Institute of Experimental Immunology, Rheinische Friedrich-Wilhelms University of Bonn, Bonn, Germany. ckurts@uni-bonn.de

European Journal of Immunology
|June 16, 2010
PubMed
Summary

Dendritic cells (DCs) can also induce tolerance in memory T helper (Th) cells, not just activate them. This finding is crucial for developing DC-based immunotherapies for autoimmune diseases.

Area of Science:

  • Immunology
  • Cell Biology
  • Autoimmunity

Background:

  • Dendritic cells (DCs) play a dual role in immunity, activating T cells against pathogens and tolerizing autoreactive T cells to prevent autoimmunity.
  • Previous research indicated that steady-state DCs induce tolerance in naive cytotoxic CD8 T lymphocytes (CTLs), naive T helper (Th) cells, and memory CTLs.

Discussion:

  • This study reveals that DCs also induce tolerance in memory Th cells, a critical subset in established autoimmune conditions.
  • Th cells are central regulators of adaptive immunity, making their tolerance induction by DCs highly significant for therapeutic strategies.

Key Insights:

  • Dendritic cells (DCs) actively induce tolerance in memory T helper (Th) cells.
  • This tolerance mechanism is vital for preventing autoimmune diseases, particularly those involving memory T cell responses.

More Related Videos

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
11:34

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

Published on: April 11, 2025

Related Experiment Videos

Last Updated: Jun 12, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
11:34

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

Published on: April 11, 2025

Outlook:

  • The findings support the potential for developing dendritic cell (DC)-based immunotherapies for common autoimmune diseases.
  • Targeting DC-mediated tolerance in memory Th cells offers a promising avenue for treating established autoimmune conditions.