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Capillary Electrophoresis: Applications

Capillary Electrophoresis: Applications

Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...

Electrophoresis: Overview

Electrophoresis: Overview

Electrophoresis is a powerful analytical separation technique that relies on the differential migration of charged species when subjected to an electric field. The core strength of electrophoresis lies in its ability to separate high-molecular-weight species in complex mixtures. It has found widespread use in biochemistry, molecular biology, and analytical chemistry, allowing the separation of compounds like amino acids, nucleotides, carbohydrates, and proteins with excellent resolution.
There...

Capillary Electrophoresis: Instrumentation

Capillary Electrophoresis: Instrumentation

Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...

iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

High-Performance Liquid Chromatography: Types of Detectors

High-Performance Liquid Chromatography: Types of Detectors

The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte properties and...

Interfacial Electrochemical Methods: Overview

Interfacial Electrochemical Methods: Overview

Interfacial electrochemical methods focus on the phenomena occurring at the boundary between an electrode and a solution, as opposed to bulk methods that concentrate on the solution's overall properties. These interfacial methods are classified as either static or dynamic based on the presence of a nonzero current in the electrochemical cell and the consistency of analyte concentrations. Static methods, such as potentiometry, measure the cell's potential without any significant current passing...

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A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

[Microchip electrochromatography: the latest developments and applications].

Junhu Wang¹, Weihua Huang, Lingjun Li

¹School of Pharmacy and Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53705, USA. jwang37@wisc.edu

Se Pu = Chinese Journal of Chromatography

|June 17, 2010

Summary

This summary is machine-generated.

This review covers advancements in microchip electrochromatography (microCEC) from 2005-2009, focusing on column technologies and chip design. It highlights practical applications, features, and limitations of this separation technique.

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A Microfluidic Chip for ICPMS Sample Introduction

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

Area of Science:

Analytical Chemistry
Separation Science

Context:

Microchip electrochromatography (microCEC) has emerged as a powerful miniaturized separation technique.
The period 2005-2009 witnessed significant progress in microchip electrochromatography.

Purpose:

To review recent developments and applications of microchip electrochromatography (microCEC).
To focus on column technologies, chip design, fabrication, and operational improvements in microCEC.
To highlight practical aspects, features, and limitations of microCEC applications.

Summary:

The review covers advancements in microchip electrochromatography (microCEC) between 2005 and 2009.
Key areas include column technologies, chip design and fabrication, sample preconcentration, and electroosmotic flow control.
Mechanisms governing electrochromatographic separation and practical application features/limitations are also discussed.

Impact:

Provides a comprehensive overview of microchip electrochromatography during a key development period.
Identifies trends and challenges in microchip electrochromatography for researchers and practitioners.
Informs future research directions in miniaturized analytical separation techniques.