Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The posterior corneal surface in posterior polymorphous dystrophy: a specular microscopical study.

H C Laganowski1, E S Sherrard, M G Muir

  • 1Moorfields Eye Hospital, London, England.

Cornea
|May 1, 1991
PubMed
Summary

Specular microscopy reveals posterior polymorphous dystrophy (PPD) involves distinct corneal vesicles and bands. These findings differentiate PPD from other posterior corneal conditions, aiding diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microbial keratitis in ITU staff: an occupational hazard?

Anaesthesia·2004
Same author

Choroidal hemangiomas: visual and anatomic results of treatment by photocoagulation or radiation therapy.

Ophthalmology·1997
Same author

Corneal complications of cataract surgery.

Current opinion in ophthalmology·1994
Same author

Excimer laser photorefractive keratectomy for myopia: comparison of 4.00- and 5.00-millimeter ablation zones.

Journal of refractive and corneal surgery·1994
Same author

Phototherapeutic keratectomy for recurrent corneal erosions.

Eye (London, England)·1994
Same author

Comparison of tear film thickness in three species determined by the glass fibre method and confocal microscopy.

Eye (London, England)·1993

Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Microscopy

Background:

  • Posterior polymorphous dystrophy (PPD) is a genetic corneal condition.
  • Diagnosis often relies on characteristic corneal opacities.
  • Distinguishing PPD from other posterior corneal disorders can be challenging.

Purpose of the Study:

  • To characterize the specular microscopy findings in posterior polymorphous dystrophy (PPD).
  • To differentiate PPD from other posterior corneal abnormalities using endothelial specular photomicroscopy (ESP).
  • To investigate potential etiological factors related to corneal rigidity in PPD.

Main Methods:

  • Study included 48 cases diagnosed with posterior polymorphous dystrophy (PPD).
  • Specular microscopy was used to examine Descemet's membrane and corneal endothelium.

Related Experiment Videos

  • Endothelial specular photomicroscopy (ESP) was employed for detailed imaging.

    • Main Results:

    • Vesicles were observed in 42% of PPD cases, bands in 48%, and diffuse abnormalities in 10%.
    • ESP provided distinctive features of PPD vesicles (pits) and bands (trenches) in Descemet's membrane.
    • Enlarged endothelial cells were common; other previously reported endothelial abnormalities were absent.
    • Corneas in affected children showed increased rigidity.

    Conclusions:

    • Specular microscopy, particularly ESP, is valuable for diagnosing PPD and distinguishing it from similar conditions.
    • PPD primarily affects Descemet's membrane, presenting as pits and trenches.
    • Corneal rigidity in pediatric PPD may offer insights into disease etiology.