Topical norfloxacin therapy in Pseudomonas corneal ulceration

We treated 12 eyes with Pseudomonas ulcerative keratitis with topical 0.3% Norfloxacin drops (Ranbaxy Laboratories). Excellent response was achieved in all eyes, resulting in complete ulcer resolution. The healing time varied from 12 to 20 days. There was a marked improvement over the pretreatment visual acuity in 11 of the 12 eyes. No systemic or ocular side effects were observed during the study period. The present study strongly suggests that topical norfloxacin is a potent and effective drug in the treatment of Pseudomonas ulcerative keratitis.