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The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
Published on: December 19, 2025
In-hospital stroke: a multi-centre prospective registry.
1Hospital Ramón y Cajal, Madrid Hospital La Fe, Valencia Hospital La Paz, Madrid, Spain.
European Journal of Neurology
|June 17, 2010
Summary
In-hospital strokes are common, with cardioembolic strokes being the most frequent. Delays in neurological assessment and treatment significantly impact patient outcomes and mortality.
Area of Science:
- Neurology
- Cardiology
- Public Health
Background:
- In-hospital strokes (IHS) represent a significant clinical challenge.
- Avoidable delays in neurological assessment for IHS are well-documented.
- This study investigates the characteristics, care, and outcomes of IHS.
Purpose of the Study:
- To analyze the clinical profiles of patients experiencing in-hospital strokes.
- To evaluate the neurological care provided to IHS patients.
- To determine the mortality rates associated with IHS.
Main Methods:
- A multi-center, 1-year prospective study involving 13 hospitals.
- Data collected included demographic and clinical characteristics, admission diagnoses, quality of care, and thrombolytic therapy.
- Mortality during hospitalization was recorded.
Main Results:
- 273 IHS patients were included; 210 had ischemic strokes (IS), 37 transient ischemic attacks (TIA), and 26 cerebral hemorrhages.
- Cardioembolic sources were present in 50.5% of patients; 28% had withdrawn antithrombotic drugs.
- Neurologist evaluation within 3 hours occurred in 52%; 15.7% received tPA, while 14.7% were excluded due to delayed neurologist contact.
- Overall mortality was 18.4%, with 41 deaths attributed to stroke or its complications.
Conclusions:
- Cardioembolic IS is the predominant stroke subtype in the hospital setting.
- Cardiac embolism, active cancer, and antithrombotic drug withdrawal are key risk factors for IHS.
- Despite thrombolysis use, delayed neurologist consultation limits treatment, contributing to high in-hospital stroke mortality.
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