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Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Updated: Jun 12, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Proton dynamics in cancer.

Veronica Huber1, Angelo De Milito, Salvador Harguindey

  • 1Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

Journal of Translational Medicine
|June 17, 2010
PubMed
Summary

Targeting cancer cell metabolism, specifically proton dynamics, offers a novel therapeutic strategy. Disrupting proton pumps and transporters may inhibit cancer growth and survival by exploiting critical metabolic differences.

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Published on: February 6, 2019

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells
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Published on: June 9, 2020

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08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Cancer is a leading global cause of death, with current therapies offering limited survival benefits for metastatic disease.
  • Tumor cells exhibit distinct metabolic alterations, including abnormal glycolysis and proton accumulation, creating a hostile microenvironment.
  • Targeting these metabolic vulnerabilities presents a promising avenue for cancer treatment.

Discussion:

  • Inhibiting proton pumps and transporters could disrupt cancer cell detoxification mechanisms.
  • This approach offers a multifaceted strategy to suppress cancer cell proliferation and survival.
  • Understanding proton dynamics in cancer cells is crucial for developing effective therapies.

Key Insights:

  • Cell metabolism, particularly proton dynamics, is a critical Achilles' heel of cancer.
  • Blocking proton pathways may represent a novel, less toxic therapeutic strategy.
  • Significant research is emerging on proton dynamics in cancer cells.

Outlook:

  • The International Society for Proton Dynamics in Cancer (ISPDC) aims to unify global research efforts.
  • Fostering translational research and interdisciplinary collaboration is essential.
  • Developing targeted, less toxic therapeutic strategies based on proton dynamics is the future goal.