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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...

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Related Experiment Video

Updated: Jun 12, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Traditional transfusion practices are changing.

John B Holcomb1

  • 1Center for Translational Injury Research, University of Texas health Science Center, 6410 Fannin, Suite 1100, Houston, TX 77030, USA. john.holcomb@uth.tmc.edu

Critical Care (London, England)
|June 17, 2010
PubMed
Summary
This summary is machine-generated.

This study challenges traditional trauma transfusion protocols. A new algorithm using fibrinogen concentrate, plasma complex concentrate, red blood cells, fresh frozen plasma, and platelets, guided by thromboelastometry, offers a physiology-driven approach for seriously injured patients.

Related Experiment Videos

Last Updated: Jun 12, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

  • Trauma resuscitation
  • Transfusion medicine
  • Coagulation management

Background:

  • Traditional trauma transfusion protocols often follow a serial approach with limited supporting data.
  • Hypovolemic trauma patients are typically resuscitated with crystalloids/colloids, followed by red blood cells (RBCs), fresh frozen plasma (FFP), and platelets.

Discussion:

  • Schochl and co-authors propose a novel, physiology-driven transfusion strategy for severely injured trauma patients.
  • This approach utilizes a thromboelastometry-based algorithm to guide the administration of fibrinogen concentrate, plasma complex concentrate, RBCs, FFP, and platelets.

Key Insights:

  • The study presents a retrospective analysis of a 5-year dataset.
  • The findings suggest a shift from traditional serial transfusion to a more dynamic, algorithm-based resuscitation.
  • This innovative concept integrates viscoelastic hemostatic assays for real-time coagulation assessment.

Outlook:

  • This research may pave the way for more individualized and effective transfusion strategies in trauma care.
  • Further prospective studies are warranted to validate this thromboelastometry-driven approach.
  • The findings highlight the evolving landscape of transfusion therapy, emphasizing physiological parameters.