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Influence of IL6R rs8192284 polymorphism status in disease activity in rheumatoid arthritis
José Ramón Lamas1, Luis Rodríguez-Rodríguez, Jezabel Varadé
1Rheumatology Service, Hospital Clínico San Carlos, 28040 Madrid, Spain.
Objective:
To analyze the influence of IL6R rs8192284 polymorphism on the disease activity of rheumatoid arthritis (RA).
Methods:
Patients with RA (n = 281) were followed for a median of 4.2 years. A total of 1143 disease activity measurements using the 28-joint count Disease Activity Score (DAS28) were performed. A mixed-effect model was used to analyze the measurements.
Results:
A statistically significant interaction was observed between IL6R rs8192284 polymorphism and the presence of anticyclic citrullinated peptide (anti-CCP) antibodies (p = 0.008). An inverse relationship between the polymorphism and DAS28 was observed depending on anti-CCP status.
Conclusion:
The anti-CCP status in patients with RA determines the association between the IL6R rs8192284 polymorphism and disease activity.
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