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Non-invasive tissue temperature measurements based on quantitative diffuse optical spectroscopy (DOS) of water
S H Chung1, A E Cerussi, S I Merritt
1Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, USA.
Physics in Medicine and Biology
|June 17, 2010
Summary
We developed a non-invasive method using diffuse optical spectroscopy (DOS) for accurate tissue temperature measurement. This technique allows simultaneous monitoring of temperature and blood oxygenation in tissues, aiding thermal diagnostics and therapies.
Area of Science:
- Biomedical Optics
- Medical Physics
- Spectroscopy
Background:
- Accurate non-invasive tissue temperature measurement is crucial for diagnostics and therapeutics.
- Conventional methods face limitations in accuracy and invasiveness.
- Diffuse optical spectroscopy (DOS) offers potential for optical measurements within tissues.
Purpose of the Study:
- To develop and validate a non-invasive method for quantitative tissue temperature measurements using Broadband diffuse optical spectroscopy (DOS).
- To enable simultaneous, co-registered measurements of tissue temperature and hemodynamic parameters.
Main Methods:
- Utilized Broadband diffuse optical spectroscopy (DOS) to analyze near-infrared (NIR) water absorption spectra.
- Employed scattering-corrected tissue water absorption spectra to differentiate temperature effects from macromolecular binding.
- Validated the method in intralipid tissue phantoms against thermistor measurements.
Main Results:
- Achieved high correlation (R=0.96) between DOS and thermistor measurements in phantoms over a 28-48°C range.
- Demonstrated successful simultaneous, continuous measurement of temperature and hemoglobin concentrations in human subjects during cold stress.
- DOS-measured temperatures in human subjects aligned with invasive deep tissue temperature studies.
Conclusions:
- Broadband diffuse optical spectroscopy (DOS) provides a viable non-invasive approach for quantitative tissue temperature monitoring.
- The method allows for co-registered measurements of absolute temperature and hemoglobin parameters in thick tissues.
- This technique holds promise for optimizing thermal diagnostics and therapeutic interventions.
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