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Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

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Related Experiment Video

Updated: Jun 12, 2026

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

Useless perinatal therapies.

Henry L Halliday1

  • 1Department of Child Health, Queen's University Belfast and Perinatal Medicine, Royal Maternity Hospital, Belfast, UK. h.halliday@qub.ac.uk

Neonatology
|June 17, 2010
PubMed
Summary
This summary is machine-generated.

This review examines ineffective and harmful perinatal therapies, contrasting them with evidence-based surfactant therapy. It highlights historical lessons and the need for long-term evaluation of neonatal care practices.

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Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
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Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Published on: January 7, 2020

Related Experiment Videos

Last Updated: Jun 12, 2026

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
11:50

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Published on: January 7, 2020

Area of Science:

  • Perinatal Medicine
  • Neonatology
  • Evidence-Based Practice

Background:

  • Historical newborn care by nurses and obstetricians, exemplified by Pierre Budin's focus on thermal regulation for low birth weight infants.
  • The evolution of neonatology as a distinct field over the past 50 years.
  • The development of surfactant therapy as a cornerstone of modern perinatal medicine, influenced by Professor Bengt Robertson's research.

Discussion:

  • Review of historically adopted but ultimately useless or harmful perinatal therapies.
  • Examples include uncontrolled oxygen, poor temperature management, feed restriction, and specific drugs like thalidomide, chloramphenicol, and corticosteroids.
  • Critique of modern inappropriate therapies adopted without sufficient long-term evaluation, despite short-term benefits.

Key Insights:

  • The critical importance of evidence-based practices in perinatal and neonatal care.
  • The historical tendency to adopt ineffective or harmful interventions in newborn care.
  • The necessity of rigorous, long-term evaluation for all new therapeutic interventions in neonatology.

Outlook:

  • Emphasizing the need to learn from past mistakes in perinatal medicine.
  • Promoting a culture of critical appraisal and long-term outcome assessment for all neonatal therapies.
  • Ensuring that advancements in neonatal care are both effective and safe for newborns.