Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Dementia

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.

Dementia l: Introduction

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

Alzheimer Disease l: Introduction

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical Study of Fibre- Reinforced Root Posts with a Ten-Year Observation Period: A Retrospective Study.

The European journal of prosthodontics and restorative dentistry·2025

Same author

["Rheuma (be-)greifen"- A multimodal teaching concept to improve rheumatology education for medical students].

Zeitschrift fur Rheumatologie·2023

Same author

Deep learning-assisted radiomics facilitates multimodal prognostication for personalized treatment strategies in low-grade glioma.

Scientific reports·2023

Same author

The effect of spironolactone on diastolic function in haemodialysis patients.

The international journal of cardiovascular imaging·2021

Same author

Fibroblast activation protein inhibitor (FAPI) PET for diagnostics and advanced targeted radiotherapy in head and neck cancers.

European journal of nuclear medicine and molecular imaging·2020

Same author

Correction to: Perfusion MRI in CNS disease: current concepts.

Neuroradiology·2020

Same journal

Der Radiologe·2024

Same journal

Der Radiologe·2024

Same journal

Der Radiologe·2024

Same journal

Der Radiologe·2024

Same journal

Der Radiologe·2022

Same journal

Der Radiologe·2022

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

[MR spectroscopy in dementia].

T Hauser¹, L Gerigk, F Giesel

¹Abteilung E010, Radiologie, Deutsches Krebsforschungszentrum (DKFZ) Heidelberg , Im Neuenheimer Feld 280, 69120, Heidelberg, Deutschland. t.hauser@dkfz.de

|June 17, 2010

Summary

This summary is machine-generated.

Magnetic Resonance Imaging (MRI) and MR spectroscopy aid in early dementia diagnosis by detecting changes beyond physical structure. These techniques offer valuable insights into cognitive decline and various dementia types.

More Related Videos

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

Related Experiment Videos

Last Updated: Jun 12, 2026

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

Area of Science:

Neuroimaging
Neurology
Biomedical Engineering

Context:

The global population is aging, leading to a rise in dementia cases.
Early and accurate diagnosis is crucial for managing dementia and cognitive impairment.
Magnetic Resonance Imaging (MRI) is a key tool in dementia diagnostics.

Purpose:

To explore the role of MR spectroscopic changes in physiological aging.
To investigate MR spectroscopic alterations in mild cognitive impairment (MCI) and various dementia subtypes.
To highlight how MR spectroscopy parameters can enhance dementia diagnosis and differential diagnosis.

Summary:

This review focuses on MR spectroscopic findings associated with normal aging.
It examines spectroscopic changes in mild cognitive impairment (MCI), Alzheimer's dementia, frontotemporal dementia, vascular dementia, and Lewy body dementia.
MR spectroscopy provides functional insights complementing morphological MRI data for improved diagnostic accuracy.

Impact:

Improved early diagnosis and differential diagnosis of various dementia types.
Potential for developing novel biomarkers for cognitive decline and neurodegenerative diseases.
Enhanced understanding of the neurobiological underpinnings of aging and dementia.