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Updated: Jun 12, 2026
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Association between coronary artery calcification using low-dose MDCT coronary angiography and bone mineral density
1Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. d11109lin@gmail.com
Insights
Subclinical coronary calcification and low bone mineral density (BMD) were not significantly associated in middle-aged individuals. This study investigated coronary artery disease (CAD) risk factors and osteoporosis, finding no significant link after adjustments.
Area of Science:
- Cardiology
- Endocrinology
- Radiology
Background:
- Conflicting results exist regarding the relationship between osteoporosis and coronary calcification.
- This study addresses the inconsistent findings by examining subclinical coronary calcification and bone mineral density (BMD).
Purpose of the Study:
- To evaluate the association between subclinical coronary calcification and osteoporosis in middle-aged men, premenopausal women, and postmenopausal women.
- Utilizing low-dose multidetector computed tomography coronary angiography (MDCT-CA) and dual-energy X-ray absorptiometry (DXA).
Main Methods:
- Enrolled 661 participants with at least one cardiac risk factor but no known coronary artery disease (CAD).
- All participants underwent same-day low-dose MDCT-CA and DXA.
- Multivariate logistic regression analysis was used to assess associations.
Main Results:
- The prevalence of calcified plaques differed significantly between men with normal and low lumbar spine BMD (P=0.042).
- No significant differences in plaque prevalence were observed between pre- and postmenopausal women with normal and low BMD at the lumbar spine and femoral neck (P>0.05).
- Multivariate analysis revealed no significant association between BMD at the lumbar spine, femoral neck, or total proximal femur and coronary artery plaque (CAP) presence across all groups (P>0.05).
Conclusions:
- The study found no significant association between subclinical coronary calcification and low BMD in middle-aged men and women.
- These findings remained consistent after controlling for age and other cardiovascular disease and osteoporosis risk factors.
Unlabelled:
Six hundred sixty-one participants who had at least one cardiac risk factor but were without known coronary heart disease underwent low-dose multidetector computed tomography coronary angiography (MDCT-CA) and dual-energy X-ray absorptiometry. The association between presence of subclinical coronary calcified plaque and low bone mineral density for the middle-aged individual was not significant after multivariate adjustment.
Introduction:
Results of previous clinical studies assessing the relationship between osteoporosis and coronary calcification are inconsistent. This study aimed to evaluate the association between subclinical coronary calcification and osteoporosis in middle-aged men, premenopausal women, and postmenopausal women by using low-dose MDCT-CA and bone mineral density (BMD).
Methods:
This study enrolled 661 participants with at least one cardiac risk factor but without known coronary artery disease (CAD). All subjects underwent low-dose MDCT-CA and dual-energy X-ray absorptiometry on the same day.
Results:
The mean age was 52.2 years for men, 44.8 years for premenopausal women, and 59.1 years for postmenopausal women. The prevalence of calcified plaques between men with normal BMD and low BMD at lumbar spine were significantly different (P=0.042). The prevalence of mixed plaque and calcified plaque between pre- and postmenopausal women with normal BMD and low BMD at lumbar spine and femoral neck were not significantly different (P>0.05). Possible association between lumbar spine, femoral neck, and total proximal femur BMD and the presence of CAP was evaluated for men, premenopausal women, and postmenopausal women using multivariate logistic regression analysis: results were not significant (P>0.05).
Conclusion:
Our study demonstrates that the association between the presence of subclinical coronary calcification and low BMD among middle-aged men and women was not significant after controlling for age and other risk factors for CAD and osteoporosis.
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