Related Experiment Video
Updated: Jun 12, 2026

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation
Published on: January 24, 2025
Antimicrobial photodynamic inactivation and photodynamic therapy for infections
Liyi Huang1, Tianhong Dai, Michael R Hamblin
1Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
Abstract:
Photodynamic therapy (PDT) was initially discovered over 100 years ago by its ability to kill microorganisms, but its use to treat infections clinically has not been much developed. However, the present relentless increase in antibiotic resistance worldwide and the emergence of strains that are resistant to all known antibiotics has stimulated research into novel antimicrobial strategies such as PDT that are thought to be unlikely to lead to the development of resistance. In this chapter we will cover the use of PDT to kill pathogenic microbial cells in vitro and describe a mouse model of localized infection and its treatment by PDT without causing excessive damage to the host tissue.
Related Concept Videos
Physical Methods for Controlling Microbial Growth: Radiation and Filtration
Hand hygiene
Hand washing...
Antimicrobial Effectiveness
Methods for Controlling Microbial Growth
Cleaning, Sterilization, and Disinfection
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
Acne Infection

