Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proteins: Dietary Sources and Requirements01:28

Proteins: Dietary Sources and Requirements

Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Dietary Connections01:23

Dietary Connections

In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used as energy sources to produce...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diet-Induced Severe Hyperhomocysteinemia Promotes Atherosclerosis Progression and Dysregulates the Plasma Metabolome in Apolipoprotein-E-Deficient Mice.

Nutrients·2024
Same author

A very-low carbohydrate content in a high-fat diet modifies the plasma metabolome and impacts systemic inflammation and experimental atherosclerosis.

The Journal of nutritional biochemistry·2024
Same author

High-field magnetic resonance microscopy of aortic plaques in a mouse model of atherosclerosis.

Magma (New York, N.Y.)·2023
Same author

Hepatocyte Nuclear Factor 4α (HNF4α) Plays a Controlling Role in Expression of the Retinoic Acid Receptor β (<i>RARβ</i>) Gene in Hepatocytes.

International journal of molecular sciences·2023
Same author

Hypovitaminosis A Drives the Progression of Tubulointerstitial Lupus Nephritis through Potentiating Predisease Cellular Autoreactivity.

ImmunoHorizons·2023
Same author

Fatty Acid Transfer from Blood to Milk Is Disrupted in Mothers with Low Milk Production, Obesity, and Inflammation.

The Journal of nutrition·2022

Related Experiment Videos

Diet in vitamin A research.

A Catharine Ross1

  • 1Department of Nutritional Sciences and Huck Institute for the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.

Methods in Molecular Biology (Clifton, N.J.)
|June 17, 2010
PubMed
Summary

Diet formulation is crucial for in vivo research, especially in retinoid studies. Purified diets precisely control vitamin A levels in rodents, mimicking human vitamin A status variations for better research outcomes.

Area of Science:

  • Nutritional science
  • Biomedical research
  • Retinoid metabolism

Background:

  • Diet is fundamental for in vivo research accuracy.
  • Retinoid research requires careful dietary control.
  • Standard rodent diets often have unknown and variable vitamin A content.

Purpose of the Study:

  • To highlight the importance of diet in retinoid research.
  • To differentiate dietary considerations in human versus animal studies.
  • To advocate for purified diets in rodent research for precise vitamin A control.

Main Methods:

  • Analysis of dietary intake in human studies.
  • Imposition of controlled diets in rodent experimental designs.
  • Utilization of well-formulated purified diets with known vitamin A content.

Related Experiment Videos

Main Results:

  • Human studies necessitate rigorous dietary intake analysis due to variability.
  • Rodent studies benefit from controlled diets for consistent experimental conditions.
  • Purified diets allow for exact vitamin A quantification and retinoid status control in rodents.

Conclusions:

  • Proper diet formulation is essential for reliable in vivo research.
  • Controlled purified diets in rodents can model diverse human vitamin A statuses.
  • Precise control over vitamin A in rodent diets enhances the interpretability and reproducibility of retinoid research.