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Updated: Jun 12, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Total synthesis and stereochemical reassignment of tasiamide B
Tiantian Sun1, Wei Zhang, Chengli Zong
1School of Pharmacy, Ocean University of China, Yushan Rd. 5, Qingdao, China.
Abstract:
The first total synthesis of tasiamide B, an octapeptide bearing 4-amino-3-hydroxy-5-phenylpentanoic acid unit isolated from the marine cyanobacteria Symploca sp. is described. A simple and efficient way was found to avoid the pyroglutamylation of N(alpha)-Me-Gln and led to a reassignment of the N(alpha)-Me-L-Phe of tasiamide B to be N(alpha)-Me-D-Phe, which was also supported by 1D and 2D NMR.
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