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Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

Enhanced prothrombin formation and platelet activation in Chinese patients after transcatheter closure of atrial

Xiao-Chun Zeng1, Wei-Feng Wu, Kai Huang

  • 1Department of Cardiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, People's Republic of China.

Clinical Cardiology
|June 17, 2010
PubMed

Insights

Transcatheter closure of atrial septal defect (ASD) increases coagulation activation but decreases platelet activation. This study found no evidence that aspirin prevents thrombus formation post-procedure.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Hematology

Background:

  • Atrial septal defect (ASD) closure is a common procedure.
  • Transcatheter closure is a minimally invasive option for ASD repair.
  • Understanding post-procedural hemostatic changes is crucial for preventing complications like embolism.

Purpose of the Study:

  • To investigate changes in coagulation and platelet activation after transcatheter ASD closure.
  • To identify specific markers of hemostatic activation over time.
  • To inform strategies for preventing postprocedural embolism.

Main Methods:

  • Prospective study of 40 patients undergoing transcatheter ASD closure with the Lifetech ASD occluder.
  • Measurement of serum prothrombin fragment 1 + 2 (F1 + 2) levels.
  • Evaluation of platelet surface markers P-selectin (CD62P) and glycoprotein IIb/IIIa receptor (CD41a) expression at baseline and at 1 day, 1 month, and 3 months post-closure.

Main Results:

  • Coagulation activation, indicated by F1 + 2 levels, increased transiently at 1 day post-closure, returning to baseline by 1 month.
  • Platelet activation markers CD62P and CD41a showed decreased expression at all measured time points after closure.
  • These findings suggest a complex interplay of hemostatic changes following transcatheter ASD closure.

Conclusions:

  • Transcatheter closure of ASD using the Lifetech occluder is linked to increased coagulation activation and reduced platelet activation.
  • The study did not find evidence to support the use of aspirin for preventing thrombus formation after this procedure.
  • Further research may explore alternative antithrombotic strategies.
Abstract

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