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Changes in enzyme activities in skin fibroblasts derived from persons of various ages
Y Shindo1, J Akiyama, Y Yamazaki
1Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
Experimental Gerontology
|January 1, 1991
Abstract:
We examined antioxidant enzyme activities (catalase, glutathione peroxidase, and superoxide dismutase) in cultured skin fibroblasts (passage number 2-3) derived from 30 persons of various ages. With increasing ages, catalase activity decreased, glutathione peroxidase activity increased slightly, and superoxide dismutase activity was unchanged. After UVA irradiation (4.8 joule/cm2) of the fibroblasts, only catalase activity decreased by 70%. This suggests that catalase may play an important role in the aging of human skin fibroblasts.