[Conformal radiotherapy for prostate cancer].

Area of Science:

• Oncology
• Radiation Oncology
• Medical Physics

Context:

• Prostate cancer treatment involves radiotherapy, with potential for acute and late radiation injuries.
• Optimizing radiotherapy techniques is crucial for improving patient outcomes and reducing toxicity.
• Retrospective analysis of 88 prostate cancer patients (T2-T4NXM0) treated between 1999-2003.

Purpose:

• To compare the efficacy and toxicity of contemporary radiotherapy versus combined treatment including radioprotector GGS-9 and 3D conformal radiotherapy (3D CRT) for prostate cancer.

Summary:

• Contemporary radiotherapy (n=37) involved total tumor doses (TTD) up to 70 Gy. Combined treatment (n=51) included GGS-9 and 3D CRT, with TTD up to 76 Gy.
• GGS-9 reduced acute radiation injury from 56.7% to 11.7% (p=0.0001). 3D CRT lowered late-onset injury from 13.5% to 3.9% (p=0.01).
• Recurrence-free survival improved from 73% with contemporary radiotherapy to 94.2% with 3D CRT (p=0.0001).

Impact:

• Combined radiotherapy with GGS-9 and 3D CRT significantly reduces acute and late radiation injuries in prostate cancer patients.
• Improved dose distribution with 3D CRT allows for higher tumor doses without increasing toxicity.
• This approach enhances local control and significantly improves 5-year recurrence-free survival rates.