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Related Experiment Video

Updated: Jun 12, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

The link between penile hypersensitivity and premature ejaculation.

Michael G Wyllie¹, Wayne J G Hellstrom

¹Plethora Solutions Ltd, High Holborn, London, UK. m.wyllie@globalpharma.co.uk

BJU International

|June 18, 2010

Summary

Penile hypersensitivity may contribute to premature ejaculation (PE). Topical anesthetic PSD502, used in clinical trials, improved ejaculatory control and satisfaction in men with PE.

Related Experiment Videos

Last Updated: Jun 12, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

Urology
Sexual Medicine
Neuroscience

Background:

Premature ejaculation (PE) is a common sexual dysfunction.
The International Society of Sexual Medicine (ISSM) provides diagnostic criteria for PE.
Penile hypersensitivity is a proposed contributing factor to PE, supported by neurophysiological data.

Purpose of the Study:

To examine the relationship between penile hypersensitivity and premature ejaculation (PE).
To evaluate the efficacy of PSD502, a topical anesthetic, in treating PE.
To assess the role of sensory afferents in the ejaculatory reflex.

Main Methods:

Review of historical neurophysiological data.
Analysis of data from clinical trials of PSD502, including a double-blind study.
Utilizing PSD502's local anesthetic properties as an indicator of sensory afferent involvement in ejaculation.

Main Results:

Published data does not definitively confirm penile hypersensitivity as the sole cause of PE.
Variability in PE population definitions across studies complicates interpretation.
PSD502 significantly increased ejaculatory latency and improved control and satisfaction in men with PE compared to placebo.

Conclusions:

The effectiveness of PSD502 supports the penile hypersensitivity hypothesis for PE.
PSD502's mechanism, reducing neuronal firing in sensory afferents, suggests hypersensitivity in PE patients.
Improved ejaculatory function with PSD502, without generalized penile desensitization, points to underlying hypersensitivity.