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Updated: Jun 12, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
No significant association between RELN polymorphism and autism in case-control and family-based association study in
Yiqun He1, Guanglei Xun, Kun Xia
1Mental Health Institute of the Second Xiangya Hospital, Central South University, 139# Renmin Middle Road, Changsha, Hunan, China.
Abstract:
The present study genotyped four SNPs (rs736707, rs2229864, rs362691, and rs2073559) of the Reelin gene (RELN) in 165 autistic trios, 67 sporadic autistic children and 283 healthy controls with Chinese Han pedigree. Both case-control analysis and transmission disequilibrium test (TDT) found no evidence of significant association. The results do not support previous positive findings and suggest that the four single-nucleotide polymorphisms (SNP) of RELN are unlikely to be associated with childhood autism in Chinese Han population.
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