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Naloxone modifies the inotropic decrease induced by halothane on isolated left atria
M L Laorden1, M D Carceles, F S Miralles
1Department of Physiology and Pharmacology, School of Medicine, Murcia, Spain.
General Pharmacology
|January 1, 1991
Abstract:
1. The present study evaluates the interaction between naloxone and halothane on the left atria. 2. Halothane produced significant decrease in auricular inotropism at concentrations ranging from 0.3 to 2.5 v/v%. 3. Naloxone modified the concentration response curve to halothane. The antagonism between both drugs is consistent with a competitive antagonism since the curve obtained had a slope which did not differ significantly from -1. 4. These results suggest that the negative inotropic effects induced by halothane could be mediated by opioid receptors.