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Caught in the act: in vivo development of macrolide resistance to Campylobacter jejuni infection

J C Lindow1, F Poly, D R Tribble

  • 1Vaccine Testing Center, University of Vermont College of Medicine, Department of Medicine, Burlington, VT 05405, USA. janet.lindow@uvm.edu

Journal of Clinical Microbiology
|June 18, 2010
PubMed

Insights

Macrolide resistance emerged in vivo in Campylobacter jejuni during a controlled human infection study. This finding highlights the potential for in vivo resistance development to contribute to Campylobacter antibiotic resistance.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Campylobacter jejuni is a leading cause of bacterial gastroenteritis worldwide.
  • Antibiotic resistance in C. jejuni poses a significant public health threat.
  • Macrolides are a critical class of antibiotics used to treat C. jejuni infections.

Observation:

  • A controlled human infection model was used with a healthy volunteer.
  • Appropriate antibiotic treatment with a macrolide was administered.
  • Macrolide resistance was observed to develop in vivo during the infection.

Findings:

  • This study documents the first instance of macrolide resistance developing in vivo in C. jejuni.
  • The development of resistance occurred despite appropriate antibiotic use.
  • In vivo resistance emergence is identified as a potential driver of overall antibiotic resistance in C. jejuni.

Implications:

  • The findings underscore the need for careful monitoring of antibiotic resistance development.
  • Understanding in vivo resistance mechanisms is crucial for effective C. jejuni treatment strategies.
  • This research contributes to the broader understanding of antimicrobial resistance dynamics in bacterial pathogens.

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