Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
Glial Cells01:04

Glial Cells

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping High-Rate Clusters of Animal Contact-Related Human Salmonella enterica Single-State Outbreaks in the United States, 2009-2022: A Spatial Epidemiological Approach to Inform Public Health Surveillance.

Zoonoses and public health·2026
Same author

Hippocampal Long Axis Differentiation in Memory and Seizure Networks.

Epilepsy currents·2026
Same author

Multistate animal-contact-related nontyphoidal Salmonella enterica outbreaks in the United States, 2009-2022: Network and machine learning analyses of exposure sources, settings, and serovars.

PloS one·2026
Same author

Evaluating biosecurity practices across beef cattle production types in Illinois, USA: Differences in disease prevention and preparedness.

Preventive veterinary medicine·2026
Same author

Assessing antimicrobial resistance in Shiga toxin-producing <i>Escherichia coli</i> O157 isolates from human clinical cases in the United States, 2010-2021.

Future microbiology·2026
Same author

Profiling of Antimicrobial Resistance Genes and Genotype-Phenotype Associations in <i>Salmonella</i> spp. Isolated Along the Broiler Production Chain in Karnataka, India.

International journal of food science·2026

Related Experiment Video

Updated: Jun 12, 2026

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice
07:00

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

Published on: August 2, 2024

Granule cells in the CA3 area.

János Szabadics1, Csaba Varga, János Brunner

  • 1Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, California 92697, USA. szabadicsj@koki.hu

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|June 18, 2010
PubMed
Summary
This summary is machine-generated.

Researchers discovered a new type of glutamatergic neuron, CA3 granule cells, in the hippocampus. These cells, unlike typical neurons, are glutamatergic nonprincipal cells with unique GABAergic inputs, challenging established neuronal network properties.

More Related Videos

Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons
11:21

Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons

Published on: November 20, 2018

Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development
04:20

Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development

Published on: June 9, 2021

Related Experiment Videos

Last Updated: Jun 12, 2026

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice
07:00

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

Published on: August 2, 2024

Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons
11:21

Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons

Published on: November 20, 2018

Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development
04:20

Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development

Published on: June 9, 2021

Area of Science:

  • Neuroscience
  • Cell Biology
  • Neuroanatomy

Background:

  • The hippocampus, specifically Ammon's horn, is characterized by a primary glutamatergic principal cell population and diverse GABAergic interneurons.
  • A fundamental organizational principle posits a single glutamatergic cell type per hippocampal area.

Purpose of the Study:

  • To identify and characterize an exception to the rule of single glutamatergic cell populations in hippocampal areas.
  • To investigate the properties and synaptic integration of newly identified granule cells within the CA3 region.

Main Methods:

  • Histological analysis of rat hippocampi to locate and identify CA3 granule cells.
  • Electrophysiological recordings (paired recordings) to assess intrinsic properties and synaptic connections.
  • Immunohistochemistry to examine co-expression of specific neuronal markers (calbindin, Prox1, cholecystokinin).

Main Results:

  • Identified glutamatergic granule cells within the CA3 area, distinct from the dentate gyrus.
  • CA3 granule cells exhibit similar morphology and intrinsic properties to dentate gyrus granule cells but possess unique GABAergic inputs.
  • Demonstrated that CA3 granule cells form giant mossy fiber terminals and receive specific GABAergic innervation from cholecystokinin-expressing cells with endocannabinoid-mediated inhibition.

Conclusions:

  • CA3 granule cells represent a novel glutamatergic, nonprincipal neuronal subtype within the CA3 synaptic network.
  • These findings challenge the established model of hippocampal neuronal organization.
  • The unique inhibitory inputs suggest specialized roles for CA3 granule cells in hippocampal circuitry.