Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Swine Model of Biofilm Infection and Invisible Wounds

Swine Model of Biofilm Infection and Invisible Wounds

Published on: June 16, 2023

A non-traumatic Staphylococcus aureus osteomyelitis model in pigs.

Henrik Elvang Jensen¹, Ole Lerberg Nielsen, Jørgen Steen Agerholm

¹Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Ridebanevej 3, DK-1870, Frederiksberg C, Denmark. elvang@life.ku.dk

In Vivo (Athens, Greece)

|June 18, 2010

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cerebral hemangioma in a 5-month-old Chow Chow dog displaying seizures of acute onset.

Acta veterinaria Scandinavica·2026

Same author

Comparative evaluation of post-mortem methods for detection of diarrhoea in early-life piglets.

Porcine health management·2026

Same author

Computational Quantification of Collagen Density and Ki67-Positive Cells in a Forensic Porcine Wound Model.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026

Same author

Digital quantification of nuclei in porcine experimental and forensic wounds: effects of wound age and body location on nuclei density.

Acta veterinaria Scandinavica·2026

Same author

MethylSense: high accuracy machine learning-based diagnostics for <i>Aspergillus fumigatus</i> infection in chickens using host cell-free DNA methylation and Nanopore sequencing.

Journal of clinical microbiology·2026

Same author

Experimental inoculation of pigs with porcine parainfluenza virus 1 revealed pathological manifestations in the upper respiratory tract.

PLoS pathogens·2026

Juvenile pigs challenged with Staphylococcus aureus developed bone lesions similar to human osteomyelitis. This pig model accurately reflects disease progression and can aid in studying Staphylococcus aureus infections.

Area of Science:

Veterinary Pathology
Bacterial Pathogenesis
Comparative Medicine

Background:

Juvenile pigs share bone bacterial localization susceptibility with humans.
Staphylococcus aureus is a primary cause of osteomyelitis in both species.
Hematogenous osteomyelitis is prevalent in human infants and children.

Purpose of the Study:

To assess the pig as a suitable model for studying Staphylococcus aureus-induced osteomyelitis.
To investigate the development of osteomyelitis following hematogenous bacterial spread in pigs.

Main Methods:

Twelve pigs were intravenously inoculated with Staphylococcus aureus.
Animals were euthanased at intervals from 6 to 48 hours post-infection.
Tissues (lungs, bones) were analyzed using histology and immunohistochemistry.

More Related Videos

Animal Model of Implant-Associated Infections in Mice

Animal Model of Implant-Associated Infections in Mice

Published on: June 27, 2025

A Minimally Invasive Model of Aortic Stenosis in Swine

A Minimally Invasive Model of Aortic Stenosis in Swine

Published on: October 20, 2023

Related Experiment Videos

Last Updated: Jun 12, 2026

Swine Model of Biofilm Infection and Invisible Wounds

Swine Model of Biofilm Infection and Invisible Wounds

Published on: June 16, 2023

Animal Model of Implant-Associated Infections in Mice

Animal Model of Implant-Associated Infections in Mice

Published on: June 27, 2025

A Minimally Invasive Model of Aortic Stenosis in Swine

A Minimally Invasive Model of Aortic Stenosis in Swine

Published on: October 20, 2023

Main Results:

Pulmonary microabscesses appeared by 6 hours and resolved by 48 hours.
Bone microabscesses formed by 12 hours and progressed over 48 hours.
Lesions spread within bones, sometimes bypassing the growth plate via transphyseal channels, leading to osteosis.

Conclusions:

The pig model demonstrated lesion development mirroring human osteomyelitis, particularly in children.
This model is reliable for studying osteomyelitis pathophysiology, morphology, virulence, and therapeutic interventions.