Related Experiment Video
Updated: Jun 12, 2026
05:28
Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
Stopping sepsis by targeting sphingosine kinase 1
1School of Biochemistry and Immunology, Trinity College, Dublin, Ireland. laoneill@tcd.ie
Science Translational Medicine
|June 18, 2010
Abstract:
Each year, more than a half million people in the United States alone die from sepsis, a dire multisystem disease with highly inadequate treatment options. In a recent issue of Science, Puneet and colleagues provide compelling evidence that inhibiting sphingosine kinase 1--an enzyme that resides in immune cells and is activated by inflammatory signals--might have great potential as a therapy for septic shock.
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