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Related Experiment Video

Updated: Jun 12, 2026

How to Obtain Reliable Visual Event-related Potentials in Newborns

How to Obtain Reliable Visual Event-related Potentials in Newborns

Published on: October 24, 2019

Repolarization abnormalities in the newborn.

Peter J Schwartz¹, Marco Stramba-Badiale

¹Section of Cardiology, Department of Lung, Blood and Heart, University of Pavia, Pavia, Italy. peter.schwartz@unipv.it

Journal of Cardiovascular Pharmacology

|June 18, 2010

Summary

Widespread electrocardiographic screening in newborns can identify infants with long QT syndrome (LQTS), enabling early intervention and preventing sudden infant death. This approach also helps detect affected family members and silent mutation carriers.

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Last Updated: Jun 12, 2026

How to Obtain Reliable Visual Event-related Potentials in Newborns

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Published on: October 24, 2019

Noninvasive Electrocardiography in the Perinatal Mouse

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Published on: June 12, 2020

P50 Sensory Gating in Infants

P50 Sensory Gating in Infants

Published on: December 26, 2013

Area of Science:

Cardiology
Pediatrics
Genetics

Background:

Ventricular repolarization abnormalities in newborns may indicate long QT syndrome (LQTS).
Early identification and management of LQTS are crucial for preventing life-threatening arrhythmias and sudden death in infants.

Purpose of the Study:

To provide guidelines for accurate QT interval measurement in newborns.
To establish normative QT interval values in the first month of life.
To assess the utility of electrocardiographic screening for LQTS in newborns.

Main Methods:

Prospective study of over 44,000 infants to determine QT interval distribution.
Analysis of QTc intervals from two recordings to estimate the probability of disease-causing mutations.
Evaluation of electrocardiographic screening for early LQTS detection.

Main Results:

Widespread newborn electrocardiographic screening can identify most infants with LQTS and marked QT prolongation.
Disease-causing LQTS mutations were found in 51% of family members of affected infants.
Early identification facilitates the detection of 'silent mutation carriers' within families.

Conclusions:

Electrocardiographic screening in newborns is effective for early LQTS identification, risk stratification, and prevention of sudden death.
Screening allows for the identification of affected family members, including asymptomatic carriers.
Failure to inform parents about LQTS prevalence and diagnostic/therapeutic options has medicolegal implications.