Laser-induced hyperthermia of ocular tumors

Experimental results for the optical distribution and temperature rise during laser irradiation of tumors are presented. The experimental conditions are chosen to simulate laser irradiation of ocular tumors. The tumor models are human retinoblastoma heterotransplanted in athymic mice, murine mammary carcinoma in C3H/HEJ mice, and B16 melanotic melanoma in C57/BL6 mice. The experimental results are discussed in terms of a mathematical model where the thermal distribution is calculated from the bioheat transfer equation, and the optical distribution is determined according to diffusion theory.