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Related Experiment Videos

Renal dysfunction in septicemic newborns.

G Jayashree1, A Saili, M S Sarna

  • 1Department of Pediatrics, Kalawati Saran Children's Hospital, Lady Hardinge Medical College, New Delhi.

Indian Pediatrics
|January 1, 1991
PubMed
Summary
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Nearly 15% of neonates with septicemia developed acute renal failure (ARF), often oliguric. Septicemic neonates with ARF faced significantly higher mortality, especially those with oliguric ARF.

Area of Science:

  • Neonatal Medicine
  • Pediatric Nephrology
  • Critical Care

Background:

  • Neonatal sepsis is a critical condition associated with significant morbidity.
  • Acute renal failure (ARF) is a recognized complication in critically ill neonates.
  • Early identification and management of ARF in septicemia are crucial for improving outcomes.

Purpose of the Study:

  • To determine the incidence of ARF in neonates with septicemia.
  • To characterize the type of ARF (oliguric vs. non-oliguric) in this population.
  • To assess the impact of ARF on mortality rates in septicemic neonates.

Main Methods:

  • A cohort of 30 neonates diagnosed with septicemia was studied.
  • ARF was diagnosed in neonates with renal dysfunction unresponsive to fluid and diuretic challenges.

Related Experiment Videos

  • Renal function tests were performed to evaluate kidney function.

    • Main Results:

    • Approximately 15% of neonates with septicemia developed ARF.
    • The majority of ARF cases in this cohort were oliguric.
    • Neonates with ARF exhibited significantly higher mortality compared to those without ARF.
    • Mortality was notably higher in neonates with oliguric ARF than non-oliguric ARF.

    Conclusions:

    • ARF is a significant complication in neonatal septicemia, with a notable incidence rate.
    • Oliguric ARF is a common presentation and is associated with a poorer prognosis.
    • Aggressive management and monitoring for ARF in septicemic neonates are essential to reduce mortality.