Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 12, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Relationship Between White Matter Integrity, Attention, and Memory in Schizophrenia: A Diffusion Tensor Imaging

Marek Kubicki, Margaret Niznikiewicz, Elizabeth Connor

    Brain Imaging and Behavior
    |June 18, 2010
    PubMed
    Summary

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neuroanatomy of substantia nigra and ventral tegmental area dopaminergic, and dorsal raphe serotonergic circuits in the human brain using T1-weighted and diffusion magnetic resonance imaging: A morphometric pilot study with estimate of reliability.

    bioRxiv : the preprint server for biology·2026
    Same author

    Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity.

    Biological psychiatry global open science·2026
    Same author

    Alterations in CSF Amyloid-β and Tau Biomarkers in Former College and Professional American Football Players: Findings from the DIAGNOSE CTE Research Project.

    Journal of neurotrauma·2026
    Same author

    Electroconvulsive therapy is associated with a decrease in anhedonia and axial diffusivity in the medial forebrain bundle in major depressive disorder.

    Journal of affective disorders·2025
    Same author

    Altered Cortical Gyrification Is Associated with Cortical and White Matter Microstructure in Individuals with Early Psychosis: A Multimodal Neuroimaging Study.

    Schizophrenia bulletin·2025
    Same author

    Real-time fMRI neurofeedback modulates auditory cortex activity and connectivity in schizophrenia patients with auditory hallucinations: A controlled study.

    Psychiatry research. Neuroimaging·2025

    Schizophrenia patients show reduced Cingulum Bundle (CB) integrity, impacting executive functions like attention. This disruption in white matter connectivity is linked to cognitive deficits in schizophrenia, particularly affecting the Negative Priming effect.

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Cognitive Psychology

    Background:

    • Schizophrenia is characterized by significant attention and memory deficits.
    • Disrupted anatomical connectivity in attentional control networks is hypothesized to underlie these cognitive abnormalities.

    Purpose of the Study:

    • To investigate the integrity of the Cingulum Bundle (CB), a key white matter tract, in schizophrenia patients.
    • To examine the relationship between CB integrity and executive functions, specifically using the Stroop and Negative Priming (NP) paradigms.

    Main Methods:

    • Diffusion Tensor Tractography (DTT) was employed to assess CB integrity.
    • Fractional Anisotropy (FA) was calculated along CB pathways.
    • Correlations were analyzed between FA values and performance on the Stroop and NP tasks.
    Keywords:
    attentiondiffusionmemoryschizophreniawhite matter

    More Related Videos

    Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
    09:33

    Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

    Published on: July 28, 2013

    Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
    10:33

    Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

    Published on: August 14, 2019

    Related Experiment Videos

    Last Updated: Jun 12, 2026

    Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
    12:21

    Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

    Published on: September 12, 2011

    Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
    09:33

    Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

    Published on: July 28, 2013

    Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
    10:33

    Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

    Published on: August 14, 2019

    Main Results:

    • Patients with schizophrenia exhibited decreased CB integrity and a diminished NP effect compared to controls.
    • Both groups demonstrated a significant Stroop effect.
    • In schizophrenia patients, reaction times for Stroop items and the Stroop effect correlated with left CB FA.

    Conclusions:

    • Disruptions in Cingulum Bundle integrity are associated with compromised executive functions in schizophrenia.
    • These findings highlight the role of white matter abnormalities in the cognitive disturbances observed in schizophrenia.