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Updated: Jun 12, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
[Prosthetic valve thrombosis in a patient with antiphospholipid syndrome. Report of one case]
Pilar Alaminos García1, Manuel Jesús Menduiña G, Rafael De La Chica Ruiz-Ruano
1Servicio de Cuidados Críticos y Urgencias, Hospital Universitario Virgen de las Nieves, Granada, España. menduina@terra.es
Abstract:
Primary antiphospholipid syndrome (APS) is a thrombophilic disorder not associated with connective tissue diseases or with autoimmune diseases. We report a 39-year-old female with a mechanical prosthetic mitral valve and a primary antiphospholipid syndrome. Anticoagulation with warfarin was changed for tinzaparine. Four days after the change, the patients was admitted in cardiogenic shock. A transesophageal echocardiogram showed a mass in the prosthetic valve suggestive of prosthetic thrombosis. The patient required two valve replacements due to thrombosis. Her anticardiolipin antibody titers were 84 UPL. She was discharged with a coagulation international normalized ratio of three.
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