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Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Rapidly progressive cryoglobulinemic glomerulonephritis.

Nobuo Tsuboi¹, Mayuri Ichinose, Tetsuya Kawamura

¹Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-Ku, 105-8461, Japan. nobuotsuboi@aol.com

Clinical and Experimental Nephrology

|June 18, 2010

Summary

This summary is machine-generated.

This case study highlights a rare, rapidly progressive cryoglobulinemic glomerulonephritis (CGGN) leading to irreversible kidney failure. Aggressive treatment failed to halt the severe renal deterioration in this atypical presentation.

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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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Published on: June 8, 2022

Area of Science:

Nephrology
Immunology
Pathology

Background:

Cryoglobulinemic glomerulonephritis (CGGN) typically follows a slow clinical course.
End-stage renal failure is uncommon in most CGGN patients.

Observation:

This report details an unusual CGGN case with rapid, irreversible renal decline.
The patient presented with acute renal failure post-respiratory infection, fever, and systemic symptoms.
Laboratory results showed cryoglobulinemia, low C4, and elevated anti-streptolysin O; Hepatitis C was negative.

Findings:

Renal biopsy revealed diffuse glomerular proliferation, thrombi, and subendothelial deposits.
Electron microscopy showed dense intraluminal deposits with unique annular/cylindrical structures.
These findings confirmed severe, active CGGN.

Implications:

This case underscores the potential for aggressive CGGN presentations.
It highlights the limited efficacy of current treatments in severe, rapidly progressing forms.
Further research into atypical CGGN pathogenesis and treatment is warranted.