Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rat model of experimental bacterial prostatitis.

J C Nickel1, M E Olson, J W Costerton

  • 1Department of Urology, Queen's University, Kingston General Hospital, Ontario, Canada.

Infection
|January 1, 1991
PubMed
Summary

Researchers developed a reproducible rat model for chronic bacterial prostatitis using a specific pathogen. This model mimics human disease progression, aiding the study of inflammation and infection mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nocturnal Autonomic Nervous System Dynamics and Chronic Painful Temporomandibular Disorders.

JDR clinical and translational research·2025
Same author

Mechanics- and Behavior-Related Temporomandibular Joint Differences.

Journal of dental research·2024
Same author

Individualized treatment strategy for bladder pain syndrome in female patients provides treatment recipes for successful management.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2023
Same author

Chronic Pain-Related Jaw Muscle Motor Load and Sensory Processing.

Journal of dental research·2022
Same author

Effect of Sustained Joint Loading on TMJ Disc Nutrient Environment.

Journal of dental research·2019
Same author

Mechanobehavior and Ontogenesis of the Temporomandibular Joint.

Journal of dental research·2018

Area of Science:

  • Urology
  • Infectious Diseases
  • Animal Models

Background:

  • Chronic bacterial prostatitis is a challenging condition with complex pathophysiology.
  • Existing models may not fully replicate the natural history of human disease.

Purpose of the Study:

  • To develop and validate a reproducible rat model for studying acute and chronic bacterial prostatitis.
  • To investigate the pathophysiological progression of prostatitis using microbiological, histological, ultrastructural, and immunological data.

Main Methods:

  • Development of a rat model using retrograde introduction of a defined bacterial pathogen.
  • Documentation of disease progression through microbiological, histological, ultrastructural, and immunological analyses.

Main Results:

  • The developed rat model demonstrated reproducible progression from acute to chronic bacterial prostatitis.
  • The model exhibited significant similarities to the natural history of human chronic bacterial prostatitis.
  • Comprehensive data (microbiological, histological, etc.) were collected to document inflammation and its consequences.

Conclusions:

  • The established rat model is a valuable tool for investigating the pathophysiology of bacterial prostatitis.
  • This model facilitates further research into antimicrobial and immunomodulatory strategies for chronic infective diseases.
  • Further manipulation of this model will enhance understanding of pathogenic mechanisms in chronic prostatitis.

Related Experiment Videos