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Related Experiment Videos

Chronic bacterial prostatitis: therapeutic experience with ciprofloxacin.

W Weidner1, H G Schiefer

  • 1Urologische Klinik der Georg-August-Universität Göttingen, Germany.

Infection
|January 1, 1991
PubMed
Summary

Ciprofloxacin effectively treated chronic bacterial prostatitis in men unresponsive to other antibiotics. Long-term follow-up showed pathogen eradication and clinical cure in many patients, highlighting its therapeutic potential.

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Area of Science:

  • Urology
  • Infectious Diseases
  • Pharmacology

Background:

  • Chronic bacterial prostatitis is challenging to treat.
  • Refractory cases often fail standard antibiotic regimens.

Purpose of the Study:

  • To evaluate ciprofloxacin efficacy in treating chronic bacterial prostatitis.
  • To assess long-term outcomes and pathogen eradication.

Main Methods:

  • Two studies were conducted: Study 1 (17 men) used 500 mg ciprofloxacin twice daily for 2 weeks.
  • Study 2 (16 men) used 500 mg ciprofloxacin twice daily for 4 weeks.
  • Patients had prior treatment failures with trimethoprim-sulfamethoxazole, trimethoprim, or norfloxacin.

Main Results:

  • Study 1: Eradication of Escherichia coli in 7/10 and other pathogens in 2/5 cases.

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  • Study 2: 10/16 patients achieved clinical cure with permanent eradication after a median 30-month follow-up.
  • Two patients required a second ciprofloxacin course; two discontinued due to CNS side effects.

    • Conclusions:

    • Ciprofloxacin demonstrates significant efficacy in treating refractory chronic bacterial prostatitis.
    • Longer treatment courses may improve outcomes.
    • Further research into optimal dosing and side effect management is warranted.