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Multiple sclerosis and vitamin D: a review and recommendations
Andrew J Solomon1, Ruth H Whitham
1Department of Neurology, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, CR 120, Portland, OR 97239, USA. solomoan@ohsu.edu
Current Neurology and Neuroscience Reports
|June 18, 2010
Summary
Vitamin D may play a role in multiple sclerosis (MS) risk and severity. Supplementation to maintain normal vitamin D levels appears safe for MS patients.
Area of Science:
- Neuroimmunology
- Endocrinology
- Nutritional Science
Background:
- Emerging research suggests a link between vitamin D and multiple sclerosis (MS).
- Vitamin D possesses immunomodulatory functions beyond its endocrine roles.
- Studies indicate associations between vitamin D levels, MS development risk, and disease progression.
Purpose of the Study:
- To explore the relationship between vitamin D and multiple sclerosis.
- To evaluate the potential benefits of vitamin D supplementation in MS patients.
Main Methods:
- Review of existing scientific literature on vitamin D and MS.
- Analysis of studies examining vitamin D's impact on immune function.
- Assessment of evidence for vitamin D's role in MS risk and severity.
Main Results:
- Vitamin D demonstrates significant immunomodulatory effects.
- Associations found between vitamin D levels and both MS risk and disease severity.
- Further prospective studies are needed to confirm these relationships.
Conclusions:
- Current evidence supports the potential benefits of vitamin D in managing MS.
- Vitamin D supplementation to achieve normal levels is considered reasonable and safe for individuals with MS and clinically isolated syndrome.
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