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Related Concept Videos

Borderline Personality Disorder01:25

Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...

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Related Experiment Video

Updated: Jun 12, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

Pharmacological interventions for borderline personality disorder.

Jutta Stoffers1, Birgit A Völlm, Gerta Rücker

  • 1Department of Psychiatry and Psychotherapy, Freiburg, & Department of Psychiatry and Psychotherapy, Mainz, Germany.

The Cochrane Database of Systematic Reviews
|June 18, 2010
PubMed
Summary

Second-generation antipsychotics, mood stabilizers, and omega-3 fatty acids show potential benefits for borderline personality disorder (BPD) treatment, though evidence is limited. Antidepressants are not widely supported for BPD, but may help with comorbid conditions.

Related Experiment Videos

Last Updated: Jun 12, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Trials

Background:

  • Borderline personality disorder (BPD) treatment often involves off-label drug use targeting affective and impulsive symptoms.
  • Existing drug therapies are primarily chosen based on efficacy in other psychiatric disorders.

Purpose of the Study:

  • To systematically assess the efficacy and safety of drug treatments for borderline personality disorder (BPD).

Main Methods:

  • Conducted a comprehensive literature search of bibliographic databases and contacted researchers.
  • Included randomized controlled trials comparing drugs versus placebo or other drugs in BPD patients.
  • Evaluated outcomes including BPD severity, specific symptoms, associated psychopathology, attrition, and adverse effects.

Main Results:

  • Twenty-eight trials with 1742 participants evaluated various drug classes, including antipsychotics, mood stabilizers, antidepressants, and omega-3 fatty acids.
  • Second-generation antipsychotics, mood stabilizers, and omega-3 fatty acids showed suggestive benefits, but require replication due to sparse data.
  • Antidepressants showed marginal effects and are not widely supported for BPD, though potentially useful for comorbid conditions. Olanzapine had notable adverse effects.

Conclusions:

  • Limited evidence suggests potential benefits of second-generation antipsychotics, mood stabilizers, and omega-3 fatty acids for BPD.
  • No drug significantly improved overall BPD severity or core symptoms like emptiness or identity disturbance.
  • Conclusions must be drawn cautiously due to study limitations, including small sample sizes and short observation periods.