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Whole-Body Nanoparticle Aerosol Inhalation Exposures
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Published on: May 7, 2013

Does airborne nickel exposure induce nickel sensitization?

Eugen Mann1, Ulrich Ranft, Georg Eberwein

  • 1Institut für Umweltmedizinische Forschung (IUF) an der Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.

Contact Dermatitis
|June 19, 2010
PubMed
Summary

Inhaled nickel exposure in the air may increase the risk of nickel allergy (sensitization) in children. Higher airborne nickel levels correlated with higher urinary nickel and increased nickel sensitization rates.

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Area of Science:

  • Environmental Health
  • Allergology
  • Toxicology

Background:

  • Nickel is a common cause of allergic contact dermatitis.
  • Human exposure to airborne nickel is a growing concern.

Purpose of the Study:

  • To investigate the link between airborne nickel exposure and nickel sensitization in children.
  • To assess internal nickel exposure through urinary nickel concentrations.

Main Methods:

  • Study involved 309 school-aged children in West Germany, comparing industrial and rural areas.
  • Airborne nickel exposure was assessed using air quality data and dispersion modeling.
  • Internal nickel exposure was measured via nickel concentrations in urine samples.

Main Results:

  • Nickel sensitization prevalence ranged from 12.6% to 30.7%.
  • Significant associations were found between ambient air nickel, urinary nickel, and nickel sensitization.
  • Higher airborne nickel concentrations were linked to elevated nickel sensitization prevalence.

Conclusions:

  • Inhaled nickel in ambient air may be a risk factor for developing nickel sensitization.
  • Further research with larger populations is recommended to confirm these findings.