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Updated: Jun 12, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

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Recurrent herpes simplex virus type 2 meningitis in elderly persons.

Larry E Davis¹, Jenny Guerre, Wendy H Gerstein

¹Neurology Service, New Mexico Veterans Affairs Health Care System, 1501 San Pedro Dr SE, Albuquerque, NM 87108, USA. ledavis@unm.edu

Archives of Neurology

|June 19, 2010

Summary

Recurrent herpes simplex virus type 2 (HSV-2) meningitis can occur in older adults, not just young individuals. This condition should be considered in the differential diagnosis of aseptic meningitis in the elderly population.

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Area of Science:

Neurology
Infectious Diseases
Virology

Background:

Recurrent meningitis due to herpes simplex virus type 2 (HSV-2) is typically observed in younger, sexually active adults.
The clinical presentation and demographic distribution of recurrent HSV-2 meningitis require further investigation.

Observation:

A case report details a 78-year-old patient experiencing recurrent HSV-2 meningitis 57 years after their initial genital herpes simplex infection.
A literature review of 223 patients with recurrent HSV-2 meningitis revealed that 5% were over 60 years old and 19% were over 50 years old.

Findings:

The study highlights that a significant proportion of recurrent HSV-2 meningitis cases occur in older individuals.
Age is not a limiting factor for the development of recurrent HSV-2 meningitis.

Implications:

Herpes simplex virus type 2 (HSV-2) meningitis should be included in the differential diagnosis for aseptic meningitis in elderly patients.
Clinicians should maintain a high index of suspicion for HSV-2 meningitis in older adults presenting with aseptic meningitis symptoms.