Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stress failure in pulmonary capillaries.

J B West1, K Tsukimoto, O Mathieu-Costello

  • 1Department of Medicine, University of California, San Diego, La Jolla 92093-0623.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|April 1, 1991
PubMed
Summary

High pulmonary capillary pressure can cause lung stress failure, disrupting the thin alveolar-capillary barrier. This failure, leading to protein leakage and hemorrhage, may play a role in lung diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Excess energy and photosynthesis: responses to seasonal water limitations in co-occurring woody encroachers of the semi-arid Southern Great Plains.

Photosynthetica·2024
Same author

Physical Mechanisms Providing Clinical Information From Ultrasound Lung Images: Hypotheses and Early Confirmations.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2019
Same author

Endotypes of difficult-to-control asthma in inner-city African American children.

PloS one·2017
Same author

Predawn disequilibrium between plant and soil water potentials in two cold-desert shrubs.

Oecologia·2017
Same author

Vibrational Branching Ratios and Asymmetry Parameters in the Photoionization of CO2 in the Region Between 650 Å and 840 Å.

Journal of research of the National Institute of Standards and Technology·2016
Same author

A strategy for reducing neonatal mortality at high altitude using oxygen conditioning.

Journal of perinatology : official journal of the California Perinatal Association·2015

Area of Science:

  • Pulmonary Physiology
  • Respiratory Mechanics
  • Cellular Biology

Background:

  • The alveolar-capillary membrane is crucial for gas exchange but vulnerable to mechanical stress.
  • Understanding the forces acting on pulmonary capillaries is vital for respiratory health.

Purpose of the Study:

  • To investigate the mechanical failure of pulmonary capillaries under elevated pressure.
  • To analyze the forces contributing to capillary stress failure in the mammalian lung.

Main Methods:

  • Pulmonary capillary pressure was increased in anesthetized rabbits until stress failure.
  • Analysis of circumferential wall tension, alveolar surface tension, and alveolar wall tissue tension.
  • Calculation of capillary wall stress at the point of failure.

Related Experiment Videos

Main Results:

  • Stress failure occurred at pulmonary capillary pressures >= 40 mmHg.
  • Capillary wall stress at failure was high (8 x 10^5 dyn/cm2), comparable to the aorta.
  • Circumferential wall tension was low, while alveolar surface tension and tissue tension played supporting roles.

Conclusions:

  • The lung's capillary wall has a small safety factor against stress failure at high pressures.
  • Stress failure leads to increased permeability, protein leakage, and potential hemorrhage.
  • This mechanism may contribute to the pathophysiology of various lung diseases.