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Pancreatitis associated with the use of itraconazole

J L M Passier, E P van Puijenbroek, G J P M Jonkers

    The Netherlands Journal of Medicine
    |June 19, 2010
    PubMed
    Abstract

    Insights

    Four case reports suggest itraconazole may cause pancreatitis. Recurrent use led to recurrent symptoms in two patients, highlighting a potential adverse drug reaction requiring further investigation.

    Area of Science:

    • Pharmacovigilance
    • Clinical Case Reports
    • Drug Safety

    Background:

    • Investigating a potential association between the antifungal drug itraconazole and pancreatitis.
    • Four case reports from the Netherlands are presented to highlight this assumed link.

    Observation:

    • Four Dutch case reports of pancreatitis linked to itraconazole use were reported by healthcare professionals.
    • Patients used high doses of itraconazole, with recurrence of symptoms upon re-exposure in two cases.
    • Pancreatitis diagnosis was confirmed via diagnostic tests.

    Findings:

    • The case reports suggest a plausible causal relationship between itraconazole and pancreatitis.
    • High dosage and recurrent use appear to be risk factors.

    Implications:

    • The findings underscore the need for further investigation into itraconazole-induced pancreatitis.
    • Physicians should consider this potential adverse drug reaction, especially given mild indications for itraconazole.
    • Encouraging reporting of similar cases is crucial for establishing causality.

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