Related Experiment Video
Updated: Jun 12, 2026
Retzius-Sparing Robot-Assisted Radical Prostatectomy
Published on: May 19, 2022
Outcomes of radical prostatectomy in clinically locally advanced N0M0 prostate cancer
Luigi Mearini1, Alessandro Zucchi, Elisabetta Costantini
1Urology Department, University of Perugia, Perugia, Italy. luigi.mearini@tin.it
Introduction:
Radical prostatectomy (RP) in patients with locally advanced (cT3) prostate cancer (PCa) is considered an optional therapy.
Aim:
To evaluate outcomes of surgery for cT3 disease and to compare results with those of patients treated for cT1-T2 PCa.
Patients And Methods:
Data of 74 consecutive patients with cT3 N0M0 PCa who underwent RP were compared to those of 425 consecutive unselected patients who underwent surgery for cT1-T2 N0M0 disease.
Results:
cT3: The pathological report showed a pathological downstaging in 16.3% of cases. Continence rate was 65.5%, potency rate was 38.8%, 5-year PSA-free survival was 61.9%, 5-year cancer-specific survival was 95.2%. cT1-T2: The pathological report showed a clinical downstaging in 39.1%. Continence rate was 70.8%, potency rate was 56.2%, 5-year PSA-free survival was 67.4%, 5-year cancer-specific survival was 96.0%.
Conclusions:
cT3 PCa presents challenges for the uro-oncologist since standard treatment is still under debate. RP in well-informed patients is a procedure with acceptable morbidity and should be at least a first part of a multimodality approach.
