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Updated: Jun 12, 2026

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Published on: November 21, 2013
Pilot study on schizophrenia in Sardinia
Jurg Ott1, Fabio Macciardi, Yuanyuan Shen
1Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Objective:
Based on a small sample of cases with schizophrenia and control individuals from an isolated population, a genome-wide association study was undertaken to find variants conferring susceptibility to this disease.
Methods:
Standard association tests were employed, followed by newer multilocus association methods (genotype patterns).
Results:
Individually, no variant produced a significant result. However, the best two variants (rs1360382 on chromosome 9 and rs1303 on chromosome 14) showed significantly different genotype pattern distributions between patients and control individuals. The risk genotype pattern AA-TT is highly predictive of schizophrenia, with estimated sensitivity and specificity of 1 and 0.96, respectively.
Conclusions:
These findings support the hypothesis that schizophrenia is partly due to multiple genetic variants, each with a relatively small effect.
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